VIPR2 - Vasoactive intestinal polypeptide receptor 2 - human protein (Function)
 
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VIPR2 »  Vasoactive intestinal polypeptide receptor 2  (VIP-R-2)
 
Protein also known as:  Pituitary adenylate cyclase-activating polypeptide type III receptor (PACAP-R3).
Gene name:  VIPR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Vasoactive intestinal polypeptide receptor activitydefinition[GO:0004999] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+7434  
According to Reactome, this protein belongs to the following pathway:
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: VIPR2
GenomeRNAi: 7434
PRO: PR:P41587
Chemistry
GuidetoPHARMACOLOGY: 372