HTR2B - 5-hydroxytryptamine receptor 2B - human protein (Function)
 
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HTR2B »  5-hydroxytryptamine receptor 2B
 
Gene name:  HTR2B
Entry whose protein(s) existence is based on evidence at protein level
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1 56 1
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.3.7  
GO molecular function 
Drug bindingdefinition[GO:0008144]  
8
  • IDAUniProtKB
G-protein alpha-subunit bindingdefinition[GO:0001965]  
1
  • IMPUniProtKB
Ras GTPase activator activitydefinition[GO:0005099]  
  • ISSOrtholog Curator
Serotonin bindingdefinition[GO:0051378]  
7
  • IDAUniProtKB
  • IDAMGI
Serotonin receptor activitydefinition[GO:0004993]  
3
  • IDAUniProtKB
  • IDAMGI
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
2
  • IDAUniProtKB
Behaviordefinition[GO:0007610]  
  • IEAUniProtKB KW
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • IMPUniProtKB
Cardiac muscle hypertrophydefinition[GO:0003300]  
  • ISSOrtholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
2
  • IDAUniProtKB
Cellular response to temperature stimulusdefinition[GO:0071502]  
  • ISSOrtholog Curator
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Embryonic morphogenesisdefinition[GO:0048598]  
  • ISSOrtholog Curator
ERK1 and ERK2 cascadedefinition[GO:0070371]  
1
  • IMPUniProtKB
G-protein coupled receptor internalizationdefinition[GO:0002031] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IMPUniProtKB
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
Intestine smooth muscle contractiondefinition[GO:0014827]  
2
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
  • ISSOrtholog Curator
Negative regulation of autophagydefinition[GO:0010507]  
1
  • IMPUniProtKB
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IMPUniProtKB
Neural crest cell differentiationdefinition[GO:0014033]  
  • ISSOrtholog Curator
Neural crest cell migrationdefinition[GO:0001755]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • IDAUniProtKB
Phosphorylationdefinition[GO:0016310]  
1
  • IMPUniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPUniProtKB
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • IDAUniProtKB
Positive regulation of cytokine secretiondefinition[GO:0050715]  
  • ISSOrtholog Curator
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IMPUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IDAUniProtKB
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • IDAUniProtKB
Positive regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010513]  
1
  • IDAUniProtKB
Positive regulation of Ras GTPase activitydefinition[GO:0032320] silver  
  • IEAOrtholog Compara
Protein kinase C signalingdefinition[GO:0070528]  
1
  • IMPUniProtKB
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
  • ISSOrtholog Curator
Regulation of behaviordefinition[GO:0050795]  
1
  • IMPUniProtKB
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
4
  • IMPUniProtKB
Response to drugdefinition[GO:0042493]  
3
  • IDAUniProtKB
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
1
  • IMPUniProtKB
Vasoconstrictiondefinition[GO:0042310]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3357  
Gap junction  hsa04540+3357  
Neuroactive ligand-receptor interaction  hsa04080+3357  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Serotonin receptors  REACT_17064  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT2B_receptor
GenomeRNAi: 3357
PRO: PR:P41595
Chemistry
GuidetoPHARMACOLOGY: 7