CCR2 - C-C chemokine receptor type 2 - human protein (Function)
 
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CCR2 »  C-C chemokine receptor type 2  (CCR2)
 
Protein also known as:  Monocyte chemoattractant protein 1 receptor (MCP-1-R); CD antigen CD192.
Gene name:  CCR2
Entry whose protein(s) existence is based on evidence at protein level
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1 161 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.  
1
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAInterPro 2 GO
CCR2 chemokine receptor bindingdefinition[GO:0031727]  
1
  • IDAMGI
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
GO biological process 
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cellular homeostasisdefinition[GO:0019725]  
  • ISSOrtholog Curator
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
  • ISSOrtholog Curator
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDAMGI
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • TASPINC
Negative regulation of angiogenesisdefinition[GO:0016525]  
  • ISSOrtholog Curator
Negative regulation of eosinophil degranulationdefinition[GO:0043310]  
  • ISSOrtholog Curator
Negative regulation of type 2 immune responsedefinition[GO:0002829]  
  • ISSOrtholog Curator
Positive regulation of alpha-beta T cell proliferationdefinition[GO:0046641]  
  • ISSOrtholog Curator
Positive regulation of astrocyte chemotaxisdefinition[GO:2000464]  
1
  • IDABHF-UCL
Positive regulation of CD8-positive, alpha-beta T cell extravasationdefinition[GO:2000451]  
  • ISSOrtholog Curator
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of hematopoietic stem cell migrationdefinition[GO:2000473]  
  • ISSOrtholog Curator
Positive regulation of immune complex clearance by monocytes and macrophagesdefinition[GO:0090265]  
  • ISSOrtholog Curator
Positive regulation of inflammatory responsedefinition[GO:0050729]  
  • ISSOrtholog Curator
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
  • ISSOrtholog Curator
Positive regulation of interleukin-2 productiondefinition[GO:0032743]  
  • ISSOrtholog Curator
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of monocyte extravasationdefinition[GO:2000439]  
  • ISSOrtholog Curator
Positive regulation of T cell activationdefinition[GO:0050870]  
  • ISSOrtholog Curator
Positive regulation of T cell chemotaxisdefinition[GO:0010820]  
  • ISSOrtholog Curator
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
  • ISSOrtholog Curator
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535]  
  • ISSOrtholog Curator
Regulation of vascular endothelial growth factor productiondefinition[GO:0010574]  
  • ISSOrtholog Curator
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
T-helper 17 cell chemotaxisdefinition[GO:0035705]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+729230  
Cytokine-cytokine receptor interaction  hsa04060+729230  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR2
GenomeRNAi: 729230
PRO: PR:P41597
Chemistry
GuidetoPHARMACOLOGY: 59