STAT6 - Signal transducer and activator of transcription 6 - human protein (Function)
 
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STAT6 »  Signal transducer and activator of transcription 6
 
Protein also known as:  IL-4 Stat.
Gene name:  STAT6
Entry whose protein(s) existence is based on evidence at protein level
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1 174 3
GENE REF ISO

Function

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Overview 
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Cellular response to reactive nitrogen speciesdefinition[GO:1902170] silver  
  • IEAOrtholog Compara
Interleukin-4-mediated signaling pathwaydefinition[GO:0035771]  
1
  • IMPUniProtKB
Mammary gland epithelial cell proliferationdefinition[GO:0033598] silver  
  • IEAOrtholog Compara
Mammary gland morphogenesisdefinition[GO:0060443] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of type 2 immune responsedefinition[GO:0002829] silver  
  • IEAOrtholog Compara
Positive regulation of isotype switching to IgE isotypesdefinition[GO:0048295] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
T-helper 1 cell lineage commitmentdefinition[GO:0002296] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Jak-STAT signaling pathway  hsa04630+6778  
According to Reactome, this protein belongs to the following pathways:
Downstream signal transduction  REACT_17025  
STAT6-mediated induction of chemokines  REACT_163734  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAT6
GenomeRNAi: 6778
PRO: PR:P42226