GRIA3 - Glutamate receptor 3 - human protein (Function)
 
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GRIA3 »  Glutamate receptor 3  (GluR-3)
 
Protein also known as:  Glutamate receptor ionotropic, AMPA 3 (GluA3).
Gene name:  GRIA3
Entry whose protein(s) existence is based on evidence at protein level
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1 25 2
GENE REF ISO

Function

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Overview 
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the glutamate-gated ion channel (gic) family of neurotransmitter receptors  1.A.10.1.4  
GO molecular function 
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:0004971]  
1
  • IDAUniProtKB
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234] silver  
  • IBARefGenome
GO biological process 
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
1
  • TASPINC
Ion transmembrane transportdefinition[GO:0034220]  
  • IBARefGenome
  • IEAInterPro 2 GO
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+2892  
Glutamatergic synapse  hsa04724+2892  
Long-term depression  hsa04730+2892  
Neuroactive ligand-receptor interaction  hsa04080+2892  
According to Reactome, this protein belongs to the following pathways:
Activation of AMPA receptors  REACT_18338  
Trafficking of AMPA receptors  REACT_18307  
Trafficking of GluR2-containing AMPA receptors  REACT_18422  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIA3
GenomeRNAi: 2892
PRO: PR:P42263
Chemistry
GuidetoPHARMACOLOGY: 446