PIK3CB - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform - human protein (Function)
 
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PIK3CB »  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform   [ EC 2.7.1.153 ]  (PI3Kbeta)
 
Protein also known as:  Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta (p110beta).
Gene name:  PIK3CB
Family name: PI3/PI4-kinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.  
4
  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase activitydefinition[GO:0016303] silver  
  • IBARefGenome
1-phosphatidylinositol-4-phosphate 3-kinase activitydefinition[GO:0035005] silver  
  • IBARefGenome
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Insulin receptor substrate bindingdefinition[GO:0043560] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase activitydefinition[GO:0035004]  
1
  • TASUniProtKB
Phosphatidylinositol-4,5-bisphosphate 3-kinase activitydefinition[GO:0046934] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Autophagydefinition[GO:0006914]  
  • IEAUniProtKB KW
Cell migrationdefinition[GO:0016477]  
2
  • TASUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Embryonic cleavagedefinition[GO:0040016] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASUniProtKB
Homophilic cell adhesiondefinition[GO:0007156] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • TASUniProtKB
Platelet activationdefinition[GO:0030168]  
1
  • TASUniProtKB
Platelet aggregationdefinition[GO:0070527]  
1
  • TASUniProtKB
Positive regulation of autophagydefinition[GO:0010508]  
1
  • TASUniProtKB
Regulation of cell-matrix adhesiondefinition[GO:0001952] silver  
  • IEAOrtholog Compara
Regulation of clathrin-mediated endocytosisdefinition[GO:2000369]  
1
  • TASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.1.153: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5291  
Aldosterone-regulated sodium reabsorption  hsa04960+5291  
Amoebiasis  hsa05146+5291  
Apoptosis  hsa04210+5291  
B cell receptor signaling pathway  hsa04662+5291  
Bacterial invasion of epithelial cells  hsa05100+5291  
Carbohydrate digestion and absorption  hsa04973+5291  
Chagas disease (American trypanosomiasis)  hsa05142+5291  
Chemokine signaling pathway  hsa04062+5291  
Cholinergic synapse  hsa04725+5291  
Colorectal cancer  hsa05210+5291  
Endometrial cancer  hsa05213+5291  
ErbB signaling pathway  hsa04012+5291  
Fc epsilon RI signaling pathway  hsa04664+5291  
Fc gamma R-mediated phagocytosis  hsa04666+5291  
Focal adhesion  hsa04510+5291  
Glioma  hsa05214+5291  
Hepatitis C  hsa05160+5291  
HTLV-I infection  hsa05166+5291  
Influenza A  hsa05164+5291  
Inositol phosphate metabolism  hsa00562+5291  
Insulin signaling pathway  hsa04910+5291  
Jak-STAT signaling pathway  hsa04630+5291  
Leukocyte transendothelial migration  hsa04670+5291  
Measles  hsa05162+5291  
Melanoma  hsa05218+5291  
mTOR signaling pathway  hsa04150+5291  
Natural killer cell mediated cytotoxicity  hsa04650+5291  
Neurotrophin signaling pathway  hsa04722+5291  
Non-small cell lung cancer  hsa05223+5291  
Osteoclast differentiation  hsa04380+5291  
Pancreatic cancer  hsa05212+5291  
Pathways in cancer  hsa05200+5291  
Phosphatidylinositol signaling system  hsa04070+5291  
Progesterone-mediated oocyte maturation  hsa04914+5291  
Prostate cancer  hsa05215+5291  
Regulation of actin cytoskeleton  hsa04810+5291  
Renal cell carcinoma  hsa05211+5291  
Small cell lung cancer  hsa05222+5291  
T cell receptor signaling pathway  hsa04660+5291  
Toll-like receptor signaling pathway  hsa04620+5291  
Toxoplasmosis  hsa05145+5291  
Type II diabetes mellitus  hsa04930+5291  
VEGF signaling pathway  hsa04370+5291  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 
More information is available from:
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Cell adhesion  definition   [KW-0130]
Endocytosis  definition   [KW-0254]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PIK3CB
GenomeRNAi: 5291
PRO: PR:P42338
Chemistry
GuidetoPHARMACOLOGY: 2154