CASP3 - Caspase-3 - human protein (Function)
 
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CASP3 »  Caspase-3   [ EC 3.4.22.56 ]  (CASP-3)
 
Protein also known as:  SREBP cleavage activity 1 (SCA-1). Cleaved into:  Caspase-3 subunit p12; Caspase-3 subunit p17.
Gene name:  CASP3
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 612 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.  
2
  • CuratedUniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861] silver  
  • IEAOrtholog Compara
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • IDAUniProtKB
Cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0097153]  
1
  • IMPUniProtKB
Cysteine-type endopeptidase activity involved in execution phase of apoptosisdefinition[GO:0097200]  
1
  • IMPUniProtKB
Peptidase activitydefinition[GO:0008233]  
2
  • IDAUniProtKB
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
5
  • IPIBHF-UCL
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • TASBHF-UCL
B cell homeostasisdefinition[GO:0001782] silver  
  • IEAOrtholog Compara
Cell fate commitmentdefinition[GO:0045165] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974] silver  
  • IEAOrtholog Compara
Erythrocyte differentiationdefinition[GO:0030218]  
2
  • TASUniProtKB
Execution phase of apoptosisdefinition[GO:0097194]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625] silver  
  • IEAOrtholog Compara
Glial cell apoptotic processdefinition[GO:0034349] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IBARefGenome
Negative regulation of activated T cell proliferationdefinition[GO:0046007] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IGIMGI
Negative regulation of B cell proliferationdefinition[GO:0030889] silver  
  • IEAOrtholog Compara
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736] silver  
  • IEAOrtholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IBARefGenome
Platelet formationdefinition[GO:0030220]  
1
  • TASUniProtKB
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
  • IEAOrtholog Compara
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • TASBHF-UCL
Response to UVdefinition[GO:0009411] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.56: Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by isatin sulfonamides.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+836  
Amoebiasis  hsa05146+836  
Amyotrophic lateral sclerosis (ALS)  hsa05014+836  
Apoptosis  hsa04210+836  
Colorectal cancer  hsa05210+836  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+836  
Herpes simplex infection  hsa05168+836  
Huntington's disease  hsa05016+836  
Legionellosis  hsa05134+836  
MAPK signaling pathway  hsa04010+836  
Natural killer cell mediated cytotoxicity  hsa04650+836  
p53 signaling pathway  hsa04115+836  
Parkinson's disease  hsa05012+836  
Pathways in cancer  hsa05200+836  
Pertussis  hsa05133+836  
Toxoplasmosis  hsa05145+836  
Tuberculosis  hsa05152+836  
Viral myocarditis  hsa05416+836  
According to Reactome, this protein belongs to the following pathways:
Activation of caspases through apoptosome-mediated cleavage  REACT_607  
Activation of DNA fragmentation factor  REACT_13462  
Apoptotic cleavage of cell adhesion proteins  REACT_13579  
Apoptotic cleavage of cellular proteins  REACT_107  
Caspase-mediated cleavage of cytoskeletal proteins  REACT_13541  
Degradation of the extracellular matrix  REACT_118572  
NADE modulates death signalling  REACT_13526  
Role of DCC in regulating apoptosis  REACT_22128  
Signaling by Hippo  REACT_118607  
Stimulation of the cell death response by PAK-2p34  REACT_13532  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P42574
Other
GeneWiki: Caspase_3
GenomeRNAi: 836
PRO: PR:P42574
Chemistry
GuidetoPHARMACOLOGY: 1619