CASP3 - Caspase-3 - human protein (Function)
 
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CASP3 »  Caspase-3   [ EC 3.4.22.56 ]  (CASP-3)
 
Protein also known as:  SREBP cleavage activity 1 (SCA-1). Cleaved into:  Caspase-3 subunit p12; Caspase-3 subunit p17.
Gene name:  CASP3
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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1 664 1
GENE REF ISO

Function

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Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.  
3
  • UniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861] silver  
1
  • Ortholog Compara
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
2
  • UniProtKB
Cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0097153]  
2
  • UniProtKB
Cysteine-type endopeptidase activity involved in execution phase of apoptosisdefinition[GO:0097200]  
1
  • UniProtKB
Death receptor bindingdefinition[GO:0005123] silver  
1
  • Ortholog Compara
Peptidase activitydefinition[GO:0008233]  
2
  • UniProtKB
  • MGI
Phospholipase A2 activator activitydefinition[GO:0016005] silver  
1
  • Ortholog Compara
Protease bindingdefinition[GO:0002020] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • BHF-UCL
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
GO biological process 
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • BHF-UCL
B cell homeostasisdefinition[GO:0001782] silver  
1
  • Ortholog Compara
Cell fate commitmentdefinition[GO:0045165] silver  
1
  • Ortholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Erythrocyte differentiationdefinition[GO:0030218]  
2
  • UniProtKB
Execution phase of apoptosisdefinition[GO:0097194]  
2
  • BHF-UCL
  • UniProtKB
Glial cell apoptotic processdefinition[GO:0034349] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
1
  • Ortholog Compara
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • RefGenome
Learning or memorydefinition[GO:0007611] silver  
1
  • Ortholog Compara
Negative regulation of activated T cell proliferationdefinition[GO:0046007] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • MGI
Negative regulation of B cell proliferationdefinition[GO:0030889] silver  
1
  • Ortholog Compara
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736] silver  
1
  • Ortholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182]  
1
  • RefGenome
Neurotrophin TRK receptor signaling pathwaydefinition[GO:0048011]  
1
  • MGI
Platelet formationdefinition[GO:0030220]  
1
  • UniProtKB
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to cobalt iondefinition[GO:0032025] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • BHF-UCL
Response to UVdefinition[GO:0009411] silver  
1
  • Ortholog Compara
Response to X-raydefinition[GO:0010165] silver  
1
  • Ortholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
1
  • Ortholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.56: Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by isatin sulfonamides.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+836  
Amoebiasis  hsa05146+836  
Amyotrophic lateral sclerosis (ALS)  hsa05014+836  
Apoptosis  hsa04210+836  
Colorectal cancer  hsa05210+836  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+836  
Herpes simplex infection  hsa05168+836  
Huntington's disease  hsa05016+836  
Legionellosis  hsa05134+836  
MAPK signaling pathway  hsa04010+836  
Natural killer cell mediated cytotoxicity  hsa04650+836  
p53 signaling pathway  hsa04115+836  
Parkinson's disease  hsa05012+836  
Pathways in cancer  hsa05200+836  
Pertussis  hsa05133+836  
Toxoplasmosis  hsa05145+836  
Tuberculosis  hsa05152+836  
Viral myocarditis  hsa05416+836  
According to Reactome, this protein belongs to the following pathways:
Activation of caspases through apoptosome-mediated cleavage  R-HSA-111459  
Activation of DNA fragmentation factor  R-HSA-211227  
Apoptotic cleavage of cell adhesion proteins  R-HSA-351906  
Apoptotic cleavage of cellular proteins  R-HSA-111465  
Caspase-mediated cleavage of cytoskeletal proteins  R-HSA-264870  
Degradation of the extracellular matrix  R-HSA-1474228  
Ligand-independent caspase activation via DCC  R-HSA-418889  
NADE modulates death signalling  R-HSA-205025  
Signaling by Hippo  R-HSA-2028269  
SMAC binds to IAPs  R-HSA-111463  
SMAC-mediated dissociation of IAP:caspase complexes  R-HSA-111464  
Stimulation of the cell death response by PAK-2p34  R-HSA-211736  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P42574
Other
GeneWiki: Caspase_3
GenomeRNAi: 836
PRO: PR:P42574
Chemistry
GuidetoPHARMACOLOGY: 1619