CASP2 - Caspase-2 - human protein (Function)
 
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CASP2 »  Caspase-2   [ EC 3.4.22.55 ]  (CASP-2)
 
Protein also known as:  Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2). Cleaved into:  Caspase-2 subunit p12; Caspase-2 subunit p13; Caspase-2 subunit p18.
Gene name:  CASP2
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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1 108 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0097153] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • ISSUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIBHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • TASUniProtKB
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestdefinition[GO:0006977]  
1
  • IMPUniProtKB
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
  • IEAOrtholog Compara
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • TASUniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IBARefGenome
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • TASUniProtKB
  • IBARefGenome
Luteolysisdefinition[GO:0001554] silver  
  • IEAOrtholog Compara
Neural retina developmentdefinition[GO:0003407] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Protein processingdefinition[GO:0016485]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.55: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
NADE modulates death signalling  REACT_13526  
NOD1/2 Signaling Pathway  REACT_75776  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Caspase_2
GenomeRNAi: 835
PRO: PR:P42575
Chemistry
GuidetoPHARMACOLOGY: 1618