CASP2 - Caspase-2 - human protein (Function)
 
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CASP2 »  Caspase-2   [ EC 3.4.22.55 ]  (CASP-2)
 
Protein also known as:  Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2). Cleaved into:  Caspase-2 subunit p12; Caspase-2 subunit p13; Caspase-2 subunit p18.
Gene name:  CASP2
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.  
1
  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
3
  • UniProtKB
  • BHF-UCL
Cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:0097199]  
1
  • RefGenome
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • BHF-UCL
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • RefGenome
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • UniProtKB
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestdefinition[GO:0006977]  
1
  • UniProtKB
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
1
  • Ortholog Compara
Execution phase of apoptosisdefinition[GO:0097194]  
1
  • UniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
1
  • RefGenome
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • UniProtKB
Luteolysisdefinition[GO:0001554] silver  
1
  • Ortholog Compara
Neural retina developmentdefinition[GO:0003407] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
1
  • Ortholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Protein processingdefinition[GO:0016485]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.55: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
NADE modulates death signalling  REACT_13526  
NOD1/2 Signaling Pathway  REACT_75776  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Caspase_2
GenomeRNAi: 835
PRO: PR:P42575
Chemistry
GuidetoPHARMACOLOGY: 1618