DPP6 - Dipeptidyl aminopeptidase-like protein 6 - human protein (Function)
 
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Protein
Gene
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DPP6 »  Dipeptidyl aminopeptidase-like protein 6
 
Protein also known as:  Dipeptidyl aminopeptidase-related protein.
Gene name:  DPP6
Family name: Peptidase S9B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Promotes cell surface expression of the potassium channel KCND2 (PubMed15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed18364354). Has no dipeptidyl aminopeptidase activity (PubMed8103397, PubMed15476821).  
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  • UniProtKB
GO molecular function 
Not  Dipeptidyl-peptidase activitydefinition[GO:0008239]  
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  • UniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
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  • UniProtKB
  • Ortholog Curator
Serine-type peptidase activitydefinition[GO:0008236] silver  
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  • InterPro 2 GO
GO biological process 
Neuronal action potentialdefinition[GO:0019228] silver  
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  • Ortholog Compara
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381] silver  
1
  • Ortholog Compara
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • Ortholog Curator
Proteolysisdefinition[GO:0006508] silver  
1
  • InterPro 2 GO
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
2
  • UniProtKB
  • Ortholog Curator
Enzymatic activity 
 
More information is available from:
Note 
Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DPP6
GenomeRNAi: 1804
PRO: PR:P42658