RPS27 - 40S ribosomal protein S27 - human protein (Function)
 
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RPS27 »  40S ribosomal protein S27
 
Protein also known as:  Metallopan-stimulin 1 (MPS-1).
Gene name:  RPS27
Family name: Ribosomal protein S27e
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Structural constituent of ribosomedefinition[GO:0003735]  
1
  • RefGenome
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Ribosomal small subunit assemblydefinition[GO:0000028]  
1
  • RefGenome
Translationdefinition[GO:0006412]  
4
  • UniProtKB
  • RefGenome
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+6232  
According to Reactome, this protein belongs to the following pathways:
Eukaryotic Translation Termination  R-HSA-72764  
Formation of a pool of free 40S subunits  R-HSA-72689  
Formation of the ternary complex, and subsequently, the 43S complex  R-HSA-72695  
GTP hydrolysis and joining of the 60S ribosomal subunit  R-HSA-72706  
L13a-mediated translational silencing of Ceruloplasmin expression  R-HSA-156827  
Mitotic Prometaphase  R-HSA-68877  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  R-HSA-975957  
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)  R-HSA-975956  
Peptide chain elongation  R-HSA-156902  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
Ribosomal scanning and start codon recognition  R-HSA-72702  
Separation of Sister Chromatids  R-HSA-2467813  
SRP-dependent cotranslational protein targeting to membrane  R-HSA-1799339  
Translation initiation complex formation  R-HSA-72649  
Viral mRNA Translation  R-HSA-192823  
Caution 
Was originally (PubMed8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA.  
2
  • UniProtKB
 

Keywords

Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RPS27
GenomeRNAi: 6232
PRO: PR:P42677