MATK - Megakaryocyte-associated tyrosine-protein kinase - human protein (Function)
 
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Protein
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References

 
MATK »  Megakaryocyte-associated tyrosine-protein kinase   [ EC 2.7.10.2 ]
 
Protein also known as:  Hematopoietic consensus tyrosine-lacking kinase.
Gene name:  MATK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 3
GENE REF ISO

Function

 show evidences
Overview 
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • PINC
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Mesoderm developmentdefinition[GO:0007498]  
1
  • PINC
Morphogenesis of an epitheliumdefinition[GO:0002009]  
1
  • RefGenome
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neurotrophin signaling pathway  hsa04722+4145  
According to Reactome, this protein belongs to the following pathway:
Signaling by ERBB2  REACT_115755  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Megakaryocyte-associated_tyrosine_kinase
GenomeRNAi: 4145
PRO: PR:P42679
Chemistry
GuidetoPHARMACOLOGY: 2101