MATK - Megakaryocyte-associated tyrosine-protein kinase - human protein (Function)
 
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Protein
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References

 
MATK »  Megakaryocyte-associated tyrosine-protein kinase   [ EC 2.7.10.2 ]
 
Protein also known as:  Hematopoietic consensus tyrosine-lacking kinase.
Gene name:  MATK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • TASPINC
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Mesoderm developmentdefinition[GO:0007498]  
1
  • TASPINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neurotrophin signaling pathway  hsa04722+4145  
According to Reactome, this protein belongs to the following pathway:
Signaling by ERBB2  REACT_115755  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Megakaryocyte-associated_tyrosine_kinase
GenomeRNAi: 4145
PRO: PR:P42679
Chemistry
GuidetoPHARMACOLOGY: 2101