ABL2 - Abelson tyrosine-protein kinase 2 - human protein (Function)
 
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ABL2 »  Abelson tyrosine-protein kinase 2   [ EC 2.7.10.2 ]
 
Protein also known as:  Abelson murine leukemia viral oncogene homolog 2.
Gene name:  ABL2
Entry whose protein(s) existence is based on evidence at protein level
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1 272 9
GENE REF ISO

Function

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Overview 
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.  
6
  • UniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • UniProtKB
Actin monomer bindingdefinition[GO:0003785]  
1
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Manganese ion bindingdefinition[GO:0030145]  
1
  • UniProtKB
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
2
  • UniProtKB
  • RefGenome
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • BHF-UCL
Protein kinase activitydefinition[GO:0004672]  
1
  • PINC
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Actin filament bundle assemblydefinition[GO:0051017] silver  
1
  • Ortholog Compara
Alpha-beta T cell differentiationdefinition[GO:0046632] silver  
1
  • Ortholog Compara
Bergmann glial cell differentiationdefinition[GO:0060020] silver  
1
  • Ortholog Compara
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Cellular protein localizationdefinition[GO:0034613] silver  
1
  • Ortholog Compara
Cellular protein modification processdefinition[GO:0006464]  
1
  • PINC
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • BHF-UCL
Cerebellum morphogenesisdefinition[GO:0021587] silver  
1
  • Ortholog Compara
Dendrite morphogenesisdefinition[GO:0048813] silver  
1
  • Ortholog Compara
Dendritic spine maintenancedefinition[GO:0097062] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • RefGenome
Exploration behaviordefinition[GO:0035640] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Negative regulation of cell-cell adhesiondefinition[GO:0022408] silver  
1
  • Ortholog Compara
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352] silver  
1
  • Ortholog Compara
Negative regulation of Rho protein signal transductiondefinition[GO:0035024] silver  
1
  • Ortholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
1
  • Ortholog Compara
Neuron remodelingdefinition[GO:0016322] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB
Phagocytosisdefinition[GO:0006909] silver  
1
  • Ortholog Compara
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
1
  • RefGenome
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • MGI
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
1
  • Ortholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123] silver  
1
  • Ortholog Compara
Positive regulation of interferon-gamma secretiondefinition[GO:1902715] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-2 secretiondefinition[GO:1900042] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • BHF-UCL
Positive regulation of oxidoreductase activitydefinition[GO:0051353]  
1
  • BHF-UCL
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • MGI
Positive regulation of protein bindingdefinition[GO:0032092] silver  
1
  • Ortholog Compara
Positive regulation of Wnt signaling pathway, planar cell polarity pathwaydefinition[GO:2000096] silver  
1
  • Ortholog Compara
Regulation of actin cytoskeleton reorganizationdefinition[GO:2000249]  
1
  • UniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of autophagydefinition[GO:0010506]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • UniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • UniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Regulation of endocytosisdefinition[GO:0030100]  
1
  • UniProtKB
Regulation of extracellular matrix organizationdefinition[GO:1903053] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Substrate-dependent cell migration, cell extensiondefinition[GO:0006930] silver  
1
  • Ortholog Compara
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ErbB signaling pathway  hsa04012+27  
Viral myocarditis  hsa05416+27  
According to Reactome, this protein belongs to the following pathway:
Role of Abl in Robo-Slit signaling  REACT_19230  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ABL2
GenomeRNAi: 27
PRO: PR:P42684
Chemistry
GuidetoPHARMACOLOGY: 1924