FRK - Tyrosine-protein kinase FRK - human protein (Function)
 
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FRK »  Tyrosine-protein kinase FRK   [ EC 2.7.10.2 ]
 
Protein also known as:  Nuclear tyrosine protein kinase RAK.
Gene name:  FRK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
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  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
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  • RefGenome
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fyn-related_kinase
GenomeRNAi: 2444
PRO: PR:P42685
Chemistry
GuidetoPHARMACOLOGY: 2025