IL12RB1 - Interleukin-12 receptor subunit beta-1 - human protein (Function)
 
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Protein
Gene
References

 
IL12RB1 »  Interleukin-12 receptor subunit beta-1
 
Protein also known as:  CD antigen CD212.
Gene name:  IL12RB1
Entry whose protein(s) existence is based on evidence at protein level
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1 52 3
GENE REF ISO

Function

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Overview 
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine receptor activitydefinition[GO:0004896]  
1
  • TASUniProtKB
Contributes to interleukin-12 receptor activitydefinition[GO:0016517]  
1
  • IDABHF-UCL
Contributes to interleukin-12 receptor bindingdefinition[GO:0005143]  
1
  • IPIBHF-UCL
Contributes to interleukin-23 bindingdefinition[GO:0042019]  
1
  • IPIBHF-UCL
Contributes to interleukin-23 receptor activitydefinition[GO:0042020]  
1
  • IDABHF-UCL
GO biological process 
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • IDABHF-UCL
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • TASBHF-UCL
Interleukin-12-mediated signaling pathwaydefinition[GO:0035722]  
1
  • IDAGOC
Interleukin-23-mediated signaling pathwaydefinition[GO:0038155]  
1
  • IDAGOC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • IDABHF-UCL
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
2
  • IMPBHF-UCL
Positive regulation of memory T cell differentiationdefinition[GO:0043382]  
  • ISSOrtholog Curator
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916]  
  • ISSOrtholog Curator
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of T-helper 17 cell lineage commitmentdefinition[GO:2000330]  
  • ISSOrtholog Curator
Positive regulation of T-helper 17 type immune responsedefinition[GO:2000318]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • ICBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3594  
Jak-STAT signaling pathway  hsa04630+3594  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links