ACAA2 - 3-ketoacyl-CoA thiolase, mitochondrial - human protein (Function)
 
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ACAA2 »  3-ketoacyl-CoA thiolase, mitochondrial   [ EC 2.3.1.16 ]
 
Protein also known as:  Mitochondrial 3-oxoacyl-CoA thiolase.
Gene name:  ACAA2
Family name: Thiolase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Abolishes BNIP3-mediated apoptosis and mitochondrial damage.  
1
  • CuratedUniProtKB
GO molecular function 
Acetyl-CoA C-acyltransferase activitydefinition[GO:0003988]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cholesterol biosynthetic processdefinition[GO:0006695]  
1
  • NASUniProtKB
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniPathway
Negative regulation of mitochondrial outer membrane permeabilizationdefinition[GO:1901029]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.16: Acyl-CoA + acetyl-CoA CoA + 3-oxoacyl-CoA.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fatty acid elongation  hsa00062+10449  
Fatty acid metabolism  hsa00071+10449  
Metabolic pathways  hsa01100+10449  
Valine, leucine and isoleucine degradation  hsa00280+10449  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACAA2
GenomeRNAi: 10449
PRO: PR:P42765