WAS - Wiskott-Aldrich syndrome protein - human protein (Function)
 
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Protein
Gene
References

 
WAS »  Wiskott-Aldrich syndrome protein
 
Gene name:  WAS
Entry whose protein(s) existence is based on evidence at protein level
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1 189 1
GENE REF ISO

Function

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Overview 
Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.  
3
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAInterPro 2 GO
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
Small GTPase regulator activitydefinition[GO:0005083]  
1
  • TASPINC
GO biological process 
Actin filament polymerizationdefinition[GO:0030041] silver  
  • IEAOrtholog Compara
Actin filament-based movementdefinition[GO:0030048] silver  
  • IEAOrtholog Compara
Actin polymerization or depolymerizationdefinition[GO:0008154]  
1
  • TASPINC
Blood coagulationdefinition[GO:0007596]  
1
  • TASPINC
Defense responsedefinition[GO:0006952]  
1
  • TASPINC
Endosomal transportdefinition[GO:0016197] silver  
  • IEAOrtholog Compara
Epidermis developmentdefinition[GO:0008544]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • IMPHGNC
Positive regulation of Arp2/3 complex-mediated actin nucleationdefinition[GO:2000601] silver  
  • IEAInterPro 2 GO
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • TASGOC
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+7454  
Bacterial invasion of epithelial cells  hsa05100+7454  
Chemokine signaling pathway  hsa04062+7454  
Fc gamma R-mediated phagocytosis  hsa04666+7454  
Pathogenic Escherichia coli infection  hsa05130+7454  
Regulation of actin cytoskeleton  hsa04810+7454  
Salmonella infection  hsa05132+7454  
Shigellosis  hsa05131+7454  
According to Reactome, this protein belongs to the following pathways:
Generation of second messenger molecules  REACT_12623  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links