CDKN2B - Cyclin-dependent kinase 4 inhibitor B - human protein (Function)
 
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Protein
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CDKN2B »  Cyclin-dependent kinase 4 inhibitor B
 
Protein also known as:  Multiple tumor suppressor 2 (MTS-2).
Gene name:  CDKN2B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 158 2
GENE REF ISO

Function

 show evidences
Overview 
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.  
  • CuratedUniProtKB
GO molecular function 
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861]  
2
  • NASUniProtKB
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • IMPBHF-UCL
Cellular response to extracellular stimulusdefinition[GO:0031668]  
1
  • IMPBHF-UCL
Cellular response to nutrientdefinition[GO:0031670]  
1
  • IMPBHF-UCL
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IMPBHF-UCL
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Megakaryocyte differentiationdefinition[GO:0030219]  
1
  • IEPUniProtKB
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • IMPBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPBHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • IMPBHF-UCL
Negative regulation of G1/S transition of mitotic cell cycledefinition[GO:2000134] silver  
  • IEAOrtholog Compara
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDABHF-UCL
Negative regulation of protein serine/threonine kinase activitydefinition[GO:0071901]  
2
  • NASGOC
Positive regulation of epithelial cell differentiationdefinition[GO:0030858] silver  
  • IEAOrtholog Compara
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511]  
1
  • IMPBHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • IDABHF-UCL
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+1030  
HTLV-I infection  hsa05166+1030  
Pathways in cancer  hsa05200+1030  
Small cell lung cancer  hsa05222+1030  
TGF-beta signaling pathway  hsa04350+1030  
According to Reactome, this protein belongs to the following pathways:
Cyclin D associated events in G1  REACT_821  
Oncogene Induced Senescence  REACT_169325  
Oxidative Stress Induced Senescence  REACT_169436  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDKN2B
GenomeRNAi: 1030
PRO: PR:P42772