HTT - Huntingtin - human protein (Function)
 
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HTT »  Huntingtin
 
Protein also known as:  Huntington disease protein (HD protein).
Gene name:  HTT
Family name: Huntingtin
Entry whose protein(s) existence is based on evidence at protein level
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1 351 1
GENE REF ISO

Function

 show evidences
Overview 
May play a role in microtubule-mediated transport or vesicle function.  
  • CuratedUniProtKB
GO molecular function 
Beta-tubulin bindingdefinition[GO:0048487]  
1
  • IDAUniProtKB
Diazepam bindingdefinition[GO:0050809] silver  
  • IEAOrtholog Compara
Dynactin bindingdefinition[GO:0034452]  
1
  • IPIUniProtKB
Dynein intermediate chain bindingdefinition[GO:0045505]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
P53 bindingdefinition[GO:0002039]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
16
  • IPIIntAct
  • IPIUniProtKB
Transcription factor bindingdefinition[GO:0008134] silver  
  • IBARefGenome
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Axon cargo transportdefinition[GO:0008088] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Citrulline metabolic processdefinition[GO:0000052] silver  
  • IEAOrtholog Compara
Determination of adult lifespandefinition[GO:0008340] silver  
  • IEAOrtholog Compara
Dopamine receptor signaling pathwaydefinition[GO:0007212] silver  
  • IEAOrtholog Compara
Endoplasmic reticulum organizationdefinition[GO:0007029] silver  
  • IEAOrtholog Compara
Endosomal transportdefinition[GO:0016197] silver  
  • IEAOrtholog Compara
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
  • IEAOrtholog Compara
Establishment of mitotic spindle orientationdefinition[GO:0000132]  
1
  • IMPUniProtKB
Golgi organizationdefinition[GO:0007030]  
1
  • IMPUniProtKB
Grooming behaviordefinition[GO:0007625] silver  
  • IEAOrtholog Compara
Hormone metabolic processdefinition[GO:0042445] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Iron ion homeostasisdefinition[GO:0055072] silver  
  • IEAOrtholog Compara
L-glutamate importdefinition[GO:0051938] silver  
  • IEAOrtholog Compara
Lactate biosynthetic process from pyruvatedefinition[GO:0019244] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IMPUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neural plate formationdefinition[GO:0021990] silver  
  • IEAOrtholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Neuron developmentdefinition[GO:0048666] silver  
  • IEAOrtholog Compara
Olfactory lobe developmentdefinition[GO:0021988] silver  
  • IEAOrtholog Compara
Organ developmentdefinition[GO:0048513] silver  
  • IBARefGenome
Paraxial mesoderm formationdefinition[GO:0048341] silver  
  • IEAOrtholog Compara
Protein import into nucleusdefinition[GO:0006606] silver  
  • IEAOrtholog Compara
Quinolinate biosynthetic processdefinition[GO:0019805] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane potentialdefinition[GO:0051881] silver  
  • IEAOrtholog Compara
Regulation of protein phosphatase type 2A activitydefinition[GO:0034047]  
1
  • IMPdictyBase
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Retrograde vesicle-mediated transport, Golgi to ERdefinition[GO:0006890]  
1
  • IMPUniProtKB
Social behaviordefinition[GO:0035176] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Striatum developmentdefinition[GO:0021756] silver  
  • IEAOrtholog Compara
Urea cycledefinition[GO:0000050] silver  
  • IEAOrtholog Compara
Vesicle transport along microtubuledefinition[GO:0047496]  
1
  • IMPUniProtKB
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+3064  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Huntingtin
GenomeRNAi: 3064
PRO: PR:P42858