ECE1 - Endothelin-converting enzyme 1 - human protein (Function)
 
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ECE1 »  Endothelin-converting enzyme 1   [ EC 3.4.24.71 ]  (ECE-1)
 
Gene name:  ECE1
Family name: Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
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1 87 4
GENE REF ISO

Function

 show evidences
Overview 
Converts big endothelin-1 to endothelin-1.  
1
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
2
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • ISSBHF-UCL
Peptide hormone bindingdefinition[GO:0017046]  
1
  • ICBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
GO biological process 
Bradykinin catabolic processdefinition[GO:0010815]  
1
  • IDABHF-UCL
Calcitonin catabolic processdefinition[GO:0010816]  
1
  • IDABHF-UCL
Ear developmentdefinition[GO:0043583]  
1
  • IMPBHF-UCL
Embryonic digit morphogenesisdefinition[GO:0042733]  
1
  • IMPBHF-UCL
Endothelin maturationdefinition[GO:0034959]  
1
  • IDABHF-UCL
Heart developmentdefinition[GO:0007507]  
1
  • IMPBHF-UCL
Hormone catabolic processdefinition[GO:0042447]  
1
  • IDABHF-UCL
Peptide hormone processingdefinition[GO:0016486]  
1
  • IDABHF-UCL
Pharyngeal system developmentdefinition[GO:0060037] silver  
  • IEAOrtholog Compara
Positive regulation of receptor recyclingdefinition[GO:0001921]  
1
  • IMPBHF-UCL
Protein processingdefinition[GO:0016485]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of systemic arterial blood pressure by endothelindefinition[GO:0003100]  
1
  • ICBHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • ICBHF-UCL
Substance P catabolic processdefinition[GO:0010814]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.71: Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by phosphoramidon.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Endothelin_converting_enzyme_1
GenomeRNAi: 1889
PRO: PR:P42892
Chemistry
GuidetoPHARMACOLOGY: 1615