GDF5 - Growth/differentiation factor 5 - human protein (Function)
 
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Gene
References

 
GDF5 »  Growth/differentiation factor 5  (GDF-5)
 
Protein also known as:  Cartilage-derived morphogenetic protein 1 (CDMP-1).
Gene name:  GDF5
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 106 1
GENE REF ISO

Function

 show evidences
Overview 
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed24098149, PubMed21976273, PubMed15530414, PubMed25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed11276205).  
9
  • UniProtKB
GO molecular function 
BMP bindingdefinition[GO:0036122]  
1
  • UniProtKB
Cytokine activitydefinition[GO:0005125]  
1
  • RefGenome
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
GO biological process 
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
BMP signaling pathwaydefinition[GO:0030509]  
1
  • RefGenome
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Chondroblast differentiationdefinition[GO:0060591]  
1
  • UniProtKB
Chondrocyte differentiationdefinition[GO:0002062] silver  
1
  • Ortholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Forelimb morphogenesisdefinition[GO:0035136] silver  
1
  • Ortholog Compara
Growthdefinition[GO:0040007] silver  
1
  • InterPro 2 GO
Hindlimb morphogenesisdefinition[GO:0035137] silver  
1
  • Ortholog Compara
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
1
  • UniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • BHF-UCL
Negative regulation of mesenchymal cell apoptotic processdefinition[GO:2001054] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
2
  • UniProtKB
Positive regulation of chondrocyte differentiationdefinition[GO:0032332]  
2
  • UniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
1
  • Ortholog Compara
SMAD protein import into nucleusdefinition[GO:0007184]  
1
  • UniProtKB
SMAD protein signal transductiondefinition[GO:0060395]  
3
  • UniProtKB
  • RefGenome
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+8200  
TGF-beta signaling pathway  hsa04350+8200  
According to Reactome, this protein belongs to the following pathway:
Molecules associated with elastic fibres  REACT_150331  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GDF5
GenomeRNAi: 8200
PRO: PR:P43026