GDF5 - Growth/differentiation factor 5 - human protein (Function)
 
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GDF5 »  Growth/differentiation factor 5  (GDF-5)
 
Protein also known as:  Cartilage-derived morphogenetic protein 1 (CDMP-1).
Gene name:  GDF5
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 101 1
GENE REF ISO

Function

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Overview 
Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.  
4
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • RefGenome
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • RefGenome
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
1
  • RefGenome
Cell developmentdefinition[GO:0048468]  
1
  • RefGenome
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Chondrocyte differentiationdefinition[GO:0002062] silver  
1
  • Ortholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Forelimb morphogenesisdefinition[GO:0035136] silver  
1
  • Ortholog Compara
Growthdefinition[GO:0040007] silver  
1
  • InterPro 2 GO
Hindlimb morphogenesisdefinition[GO:0035137] silver  
1
  • Ortholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • BHF-UCL
Negative regulation of mesenchymal cell apoptotic processdefinition[GO:2001054] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • RefGenome
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • RefGenome
Regulation of MAPK cascadedefinition[GO:0043408]  
1
  • RefGenome
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
1
  • Ortholog Compara
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • RefGenome
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+8200  
TGF-beta signaling pathway  hsa04350+8200  
According to Reactome, this protein belongs to the following pathway:
Molecules associated with elastic fibres  REACT_150331  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GDF5
GenomeRNAi: 8200
PRO: PR:P43026