PTGIR - Prostacyclin receptor - human protein (Function)
 
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PTGIR »  Prostacyclin receptor
 
Protein also known as:  Prostaglandin I2 receptor (PGI receptor).
Gene name:  PTGIR
Entry whose protein(s) existence is based on evidence at protein level
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1 61 1
GENE REF ISO

Function

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Overview 
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • IMPBHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
1
  • ISSBHF-UCL
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • IDABHF-UCL
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • IMPBHF-UCL
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • IMPBHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+5739  
Vascular smooth muscle contraction  hsa04270+5739  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Prostacyclin_receptor
GenomeRNAi: 5739
PRO: PR:P43119
Chemistry
GuidetoPHARMACOLOGY: 345