GLP1R - Glucagon-like peptide 1 receptor - human protein (Function)
 
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Protein
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GLP1R »  Glucagon-like peptide 1 receptor
 
Gene name:  GLP1R
Entry whose protein(s) existence is based on evidence at protein level
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1 82 1
GENE REF ISO

Function

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Overview 
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.6  
GO molecular function 
Glucagon receptor activitydefinition[GO:0004967] silver  
  • IEAInterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • IDAUniProtKB
Cellular response to glucagon stimulusdefinition[GO:0071377]  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2740  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glucagon-like_peptide_1_receptor
GenomeRNAi: 2740
PRO: PR:P43220
Chemistry
GuidetoPHARMACOLOGY: 249