CTSK - Cathepsin K - human protein (Function)
 
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CTSK »  Cathepsin K   [ EC 3.4.22.38 ]
 
Protein also known as:  Cathepsin O2.
Gene name:  CTSK
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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1 125 1
GENE REF ISO

Function

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Overview 
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.  
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IDABHF-UCL
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • IDABHF-UCL
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Fibronectin bindingdefinition[GO:0001968]  
1
  • IPIBHF-UCL
Proteoglycan bindingdefinition[GO:0043394]  
1
  • IPIBHF-UCL
GO biological process 
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Collagen catabolic processdefinition[GO:0030574]  
1
  • IDABHF-UCL
Intramembranous ossificationdefinition[GO:0001957] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.38: Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+1513  
Osteoclast differentiation  hsa04380+1513  
Rheumatoid arthritis  hsa05323+1513  
Toll-like receptor signaling pathway  hsa04620+1513  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
MHC class II antigen presentation  REACT_121399  
Trafficking and processing of endosomal TLR  REACT_118632  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cathepsin_K
GenomeRNAi: 1513
PRO: PR:P43235
Chemistry
GuidetoPHARMACOLOGY: 2350