GRK6 - G protein-coupled receptor kinase 6 - human protein (Function)
 
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GRK6 »  G protein-coupled receptor kinase 6   [ EC 2.7.11.16 ]
 
Protein also known as:  G protein-coupled receptor kinase GRK6.
Gene name:  GRK6
Entry whose protein(s) existence is based on evidence at protein level
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1 53 3
GENE REF ISO

Function

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Overview 
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
G-protein coupled receptor kinase activitydefinition[GO:0004703]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • TASPINC
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.16: ATP + [G-protein-coupled receptor] ADP + [G-protein-coupled receptor] phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2870  
Endocytosis  hsa04144+2870  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRK6
GenomeRNAi: 2870
PRO: PR:P43250
Chemistry
GuidetoPHARMACOLOGY: 1470