NAMPT - Nicotinamide phosphoribosyltransferase - human protein (Function)
 
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NAMPT »  Nicotinamide phosphoribosyltransferase   [ EC 2.4.2.12 ]  (Nampt)
 
Protein also known as:  Pre-B-cell colony-enhancing factor 1 (Pre-B cell-enhancing factor).
Gene name:  NAMPT
Family name: NAPRTase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Nicotinamide phosphoribosyltransferase activitydefinition[GO:0047280]  
  • IEAEC 2 GO
Nicotinate-nucleotide diphosphorylase (carboxylating) activitydefinition[GO:0004514] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Not  Adipose tissue developmentdefinition[GO:0060612]  
1
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Not  Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • IDABHF-UCL
NAD biosynthetic processdefinition[GO:0009435]  
  • IEAUniPathway
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.12: Nicotinamide D-ribonucleotide + diphosphate nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Nicotinate and nicotinamide metabolism  hsa00760+10135  
According to Reactome, this protein belongs to the following pathways:
Circadian Clock  REACT_24941  
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Pyridine nucleotide biosynthesis  definition   [KW-0662]
Molecular function 
Cytokine  definition   [KW-0202]
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P43490
Other
GeneWiki: Nicotinamide_phosphoribosyltransferase
GenomeRNAi: 10135
PRO: PR:P43490