NAMPT - Nicotinamide phosphoribosyltransferase - human protein (Function)
 
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NAMPT »  Nicotinamide phosphoribosyltransferase   [ EC 2.4.2.12 ]  (Nampt)
 
Protein also known as:  Pre-B-cell colony-enhancing factor 1 (Pre-B cell-enhancing factor).
Gene name:  NAMPT
Family name: NAPRTase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 40 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).  
3
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125] silver  
1
  • Ortholog Compara
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
Nicotinamide phosphoribosyltransferase activitydefinition[GO:0047280]  
1
  • EC 2 GO
Nicotinate-nucleotide diphosphorylase (carboxylating) activitydefinition[GO:0004514] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Not  Adipose tissue developmentdefinition[GO:0060612]  
1
  • BHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Not  Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • BHF-UCL
NAD biosynthetic processdefinition[GO:0009435]  
1
  • UniPathway
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770]  
1
  • BHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Response to organic cyclic compounddefinition[GO:0014070] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.2.12: Nicotinamide D-ribonucleotide + diphosphate nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.  
2
  • UniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Nicotinate and nicotinamide metabolism  hsa00760+10135  
According to Reactome, this protein belongs to the following pathways:
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Nicotinamide salvaging  REACT_11213  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Pyridine nucleotide biosynthesis  definition   [KW-0662]
Molecular function 
Cytokine  definition   [KW-0202]
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P43490
Other
GeneWiki: Nicotinamide_phosphoribosyltransferase
GenomeRNAi: 10135
PRO: PR:P43490