CHRNA4 - Neuronal acetylcholine receptor subunit alpha-4 - human protein (Function)
 
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Protein
Gene
References

 
CHRNA4 »  Neuronal acetylcholine receptor subunit alpha-4
 
Gene name:  CHRNA4
Entry whose protein(s) existence is based on evidence at protein level
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1 121 2
GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.6  
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
1
  • ICUniProtKB
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • IDAUniProtKB
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
2
  • TASDFLAT
  • IDAUniProtKB
Ligand-gated ion channel activitydefinition[GO:0015276]  
1
  • TASDFLAT
GO biological process 
Action potentialdefinition[GO:0001508]  
  • ISSOrtholog Curator
B cell activationdefinition[GO:0042113]  
  • ISSOrtholog Curator
Behavioral response to nicotinedefinition[GO:0035095]  
1
  • IMPUniProtKB
Calcium ion transportdefinition[GO:0006816]  
  • ISSOrtholog Curator
Cognitiondefinition[GO:0050890]  
1
  • IMPUniProtKB
DNA repairdefinition[GO:0006281]  
1
  • IMPUniProtKB
Exploration behaviordefinition[GO:0035640] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Ion transportdefinition[GO:0006811]  
1
  • NASUniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Membrane depolarizationdefinition[GO:0051899]  
  • ISSOrtholog Curator
Neurological system processdefinition[GO:0050877]  
2
  • IMPUniProtKB
Regulation of dopamine secretiondefinition[GO:0014059]  
  • ISSOrtholog Curator
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080]  
  • ISSOrtholog Curator
Regulation of membrane potentialdefinition[GO:0042391]  
  • ISSOrtholog Curator
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Response to nicotinedefinition[GO:0035094]  
1
  • IDAUniProtKB
Response to oxidative stressdefinition[GO:0006979]  
1
  • IMPUniProtKB
Sensory perception of paindefinition[GO:0019233]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • NASUniProtKB
Synaptic transmission, cholinergicdefinition[GO:0007271]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+1137  
Neuroactive ligand-receptor interaction  hsa04080+1137  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA4
GenomeRNAi: 1137
PRO: PR:P43681
Chemistry
GuidetoPHARMACOLOGY: 465