GATA4 - Transcription factor GATA-4 - human protein (Function)
 
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GATA4 »  Transcription factor GATA-4
 
Protein also known as:  GATA-binding factor 4.
Gene name:  GATA4
Entry whose protein(s) existence is based on evidence at protein level
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1 131 2
GENE REF ISO

Function

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Overview 
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.  
4
  • UniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • Ortholog Curator
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Co-SMAD bindingdefinition[GO:0070410]  
1
  • BHF-UCL
DNA bindingdefinition[GO:0003677]  
2
  • UniProtKB
  • Ortholog Curator
Enhancer sequence-specific DNA bindingdefinition[GO:0001158] silver  
1
  • Ortholog Compara
NFAT protein bindingdefinition[GO:0051525] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
7
  • UniProtKB
  • IntAct
  • BHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
1
  • Ortholog Compara
RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0001076]  
1
  • BHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • Ortholog Curator
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • BHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • BHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • UniProtKB
  • MGI
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Atrial septum morphogenesisdefinition[GO:0060413]  
1
  • BHF-UCL
Atrial septum primum morphogenesisdefinition[GO:0003289]  
1
  • Ortholog Curator
Atrial septum secundum morphogenesisdefinition[GO:0003290]  
1
  • BHF-UCL
Atrioventricular valve morphogenesisdefinition[GO:0003181] silver  
1
  • Ortholog Compara
BMP signaling pathwaydefinition[GO:0030509] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
1
  • Ortholog Compara
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
1
  • Ortholog Compara
Cardiac right ventricle morphogenesisdefinition[GO:0003215]  
1
  • Ortholog Curator
Cardiac ventricle morphogenesisdefinition[GO:0003208]  
1
  • BHF-UCL
Cell growth involved in cardiac muscle cell developmentdefinition[GO:0061049] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • Ortholog Curator
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Embryonic digestive tract morphogenesisdefinition[GO:0048557] silver  
1
  • Ortholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617]  
1
  • Ortholog Curator
Embryonic heart tube anterior/posterior pattern specificationdefinition[GO:0035054]  
1
  • Ortholog Curator
Endocardial cushion developmentdefinition[GO:0003197]  
2
  • BHF-UCL
  • Ortholog Curator
Endoderm developmentdefinition[GO:0007492]  
1
  • BHF-UCL
Endoderm formationdefinition[GO:0001706] silver  
1
  • Ortholog Compara
Epithelial cell fate commitmentdefinition[GO:0072148] silver  
1
  • Ortholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
1
  • Ortholog Compara
Heart loopingdefinition[GO:0001947]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Intestinal epithelial cell differentiationdefinition[GO:0060575]  
1
  • MGI
Lung lobe formationdefinition[GO:0060464] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584]  
2
  • UniProtKB
Negative regulation of autophagydefinition[GO:0010507] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • Ortholog Curator
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
1
  • Ortholog Compara
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
1
  • Ortholog Compara
Positive regulation of cardioblast differentiationdefinition[GO:0051891]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • Ortholog Curator
Regulation of cardiac muscle cell contractiondefinition[GO:0086004] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Response to drugdefinition[GO:0042493]  
1
  • BHF-UCL
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Seminiferous tubule developmentdefinition[GO:0072520] silver  
1
  • Ortholog Compara
Sertoli cell differentiationdefinition[GO:0060008] silver  
1
  • Ortholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
1
  • Ortholog Compara
SMAD protein signal transductiondefinition[GO:0060395] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • BHF-UCL
  • Ortholog Curator
Transdifferentiationdefinition[GO:0060290] silver  
1
  • Ortholog Compara
Ventricular cardiac muscle tissue developmentdefinition[GO:0003229] silver  
1
  • Ortholog Compara
Ventricular septum developmentdefinition[GO:0003281]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA4
GenomeRNAi: 2626
PRO: PR:P43694