TNNT2 - Troponin T, cardiac muscle - human protein (Function)
 
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TNNT2 »  Troponin T, cardiac muscle  (TnTc)
 
Protein also known as:  Cardiac muscle troponin T (cTnT).
Gene name:  TNNT2
Family name: Troponin T
Entry whose protein(s) existence is based on evidence at protein level
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1 181 11
GENE REF ISO

Function

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Overview 
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Isoforms  Iso 1 , Iso 6 , Iso 7 and Iso 8   Contributes to ATPase activitydefinition[GO:0016887]  
2
  • IDAUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAOrtholog Compara
Tropomyosin bindingdefinition[GO:0005523]  
1
  • IDAUniProtKB
Troponin C bindingdefinition[GO:0030172]  
2
  • IPIUniProtKB
Troponin I bindingdefinition[GO:0031013]  
1
  • IPIUniProtKB
GO biological process 
Isoforms  Iso 1 , Iso 6 , Iso 7 and Iso 8   ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
Atrial cardiac muscle tissue morphogenesisdefinition[GO:0055009] silver  
  • IEAOrtholog Compara
Muscle filament slidingdefinition[GO:0030049]  
2
  • IDAUniProtKB
Negative regulation of ATPase activitydefinition[GO:0032780]  
2
  • IDAUniProtKB
Positive regulation of ATPase activitydefinition[GO:0032781]  
2
  • IDAUniProtKB
Regulation of heart contractiondefinition[GO:0008016]  
1
  • IMPUniProtKB
Regulation of muscle contractiondefinition[GO:0006937] silver  
  • IEAInterPro 2 GO
Response to calcium iondefinition[GO:0051592]  
2
  • IMPUniProtKB
Sarcomere organizationdefinition[GO:0045214] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+7139  
Dilated cardiomyopathy  hsa05414+7139  
Hypertrophic cardiomyopathy (HCM)  hsa05410+7139  
According to Reactome, this protein belongs to the following pathway:
Muscle contraction  REACT_17044  
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TNNT2
GenomeRNAi: 7139
PRO: PR:P45379