ASPA - Aspartoacylase - human protein (Function)
 
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ASPA »  Aspartoacylase   [ EC 3.5.1.15 ]
 
Protein also known as:  Aminoacylase-2 (ACY-2).
Gene name:  ASPA
Family name: AspA/AstE » Aspartoacylase
Entry whose protein(s) existence is based on evidence at protein level
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1 35 1
GENE REF ISO

Function

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Overview 
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.  
  • CuratedUniProtKB
GO molecular function 
Aminoacylase activitydefinition[GO:0004046]  
1
  • TASPINC
Aspartoacylase activitydefinition[GO:0019807]  
  • IEAEC 2 GO
Hydrolase activity, acting on ester bondsdefinition[GO:0016788] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Aspartate catabolic processdefinition[GO:0006533]  
1
  • TASPINC
Central nervous system myelinationdefinition[GO:0022010] silver  
  • IEAOrtholog Compara
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.15: N-acyl-L-aspartate + H(2)O a carboxylate + L-aspartate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+443  
Histidine metabolism  hsa00340+443  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 443
PRO: PR:P45381