ABCG1 - ATP-binding cassette sub-family G member 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ABCG1 »  ATP-binding cassette sub-family G member 1
 
Protein also known as:  ATP-binding cassette transporter 8.
Gene name:  ABCG1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 69 8
GENE REF ISO

Function

 show evidences
Overview 
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.204.12  
GO molecular function 
ADP bindingdefinition[GO:0043531]  
1
  • BHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • BHF-UCL
Cholesterol bindingdefinition[GO:0015485]  
1
  • BHF-UCL
Cholesterol transporter activitydefinition[GO:0017127]  
1
  • BHF-UCL
Glycoprotein transporter activitydefinition[GO:0034437]  
1
  • BHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • BHF-UCL
Phospholipid transporter activitydefinition[GO:0005548]  
1
  • BHF-UCL
Isoform  Iso 4   Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein dimerization activitydefinition[GO:0046983]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
Sterol-transporting ATPase activitydefinition[GO:0034041]  
1
  • BHF-UCL
Toxin transporter activitydefinition[GO:0019534]  
1
  • BHF-UCL
GO biological process 
Amyloid precursor protein catabolic processdefinition[GO:0042987]  
1
  • BHF-UCL
Cholesterol effluxdefinition[GO:0033344]  
1
  • BHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • BHF-UCL
Detection of hormone stimulusdefinition[GO:0009720]  
1
  • UniProtKB
Glycoprotein transportdefinition[GO:0034436]  
1
  • BHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • BHF-UCL
Intracellular cholesterol transportdefinition[GO:0032367]  
1
  • BHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • BHF-UCL
Negative regulation of cholesterol storagedefinition[GO:0010887]  
1
  • BHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Phospholipid homeostasisdefinition[GO:0055091]  
1
  • BHF-UCL
Positive regulation of cholesterol biosynthetic processdefinition[GO:0045542]  
1
  • Ortholog Curator
Positive regulation of cholesterol effluxdefinition[GO:0010875] silver  
1
  • Ortholog Compara
Regulation of cholesterol esterificationdefinition[GO:0010872]  
1
  • BHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Response to high density lipoprotein particledefinition[GO:0055099] silver  
1
  • Ortholog Compara
Response to lipiddefinition[GO:0033993]  
1
  • BHF-UCL
Response to organic substancedefinition[GO:0010033]  
1
  • UniProtKB
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • Ortholog Curator
Toxin transportdefinition[GO:1901998]  
1
  • GOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+9619  
According to Reactome, this protein belongs to the following pathways:
ABCA transporters in lipid homeostasis  REACT_111158  
HDL-mediated lipid transport  REACT_13621  
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCG1
GenomeRNAi: 9619
PRO: PR:P45844