ACADSB - Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial - human protein (Function)
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ACADSB »  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial   [ EC ]  (SBCAD)
Protein also known as:  2-methyl branched chain acyl-CoA dehydrogenase (2-MEBCAD).
Gene name:  ACADSB
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.  
  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
GO biological process 
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Acyl-CoA + acceptor 2,3-dehydroacyl-CoA + reduced acceptor.  
  • CuratedUniProtKB
EC 2-methylbutanoyl-CoA + electron-transfer flavoprotein (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H(+).  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fatty acid metabolism  hsa00071+36  
Metabolic pathways  hsa01100+36  
Valine, leucine and isoleucine degradation  hsa00280+36  
According to Reactome, this protein belongs to the following pathway:
Branched-chain amino acid catabolism  REACT_197  


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 36
PRO: PR:P45954