PHKA2 - Phosphorylase b kinase regulatory subunit alpha, liver isoform - human protein (Function)
 
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PHKA2 »  Phosphorylase b kinase regulatory subunit alpha, liver isoform  (Phosphorylase kinase alpha L subunit)
 
Gene name:  PHKA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 1
GENE REF ISO

Function

 show evidences
Overview 
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.  
  • CuratedUniProtKB
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Hydrolase activity, hydrolyzing O-glycosyl compoundsdefinition[GO:0004553] silver  
  • IEAInterPro 2 GO
Phosphorylase kinase activitydefinition[GO:0004689]  
1
  • TASPINC
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASGOC
Enzymatic activity 
It is regulated in the following manner
By phosphorylation of various serine residues and by calcium.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5256  
Insulin signaling pathway  hsa04910+5256  
According to Reactome, this protein belongs to the following pathway:
Glycogen breakdown (glycogenolysis)  REACT_1008  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glycogen metabolism  definition   [KW-0321]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHKA2
GenomeRNAi: 5256
PRO: PR:P46019