GPR3 - G-protein coupled receptor 3 - human protein (Function)
 
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GPR3 »  G-protein coupled receptor 3
 
Protein also known as:  ACCA orphan receptor.
Gene name:  GPR3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • TASPINC
Regulation of meiosisdefinition[GO:0040020] silver  
  • IEAOrtholog Compara
Caution 
Was originally (PubMed12220620) thought to be a receptor for sphingosine 1-phosphate. PubMed19286662 demonstrated that it is not the case.  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR3
GenomeRNAi: 2827
PRO: PR:P46089
Chemistry
GuidetoPHARMACOLOGY: 83