HTR3A - 5-hydroxytryptamine receptor 3A - human protein (Function)
 
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HTR3A »  5-hydroxytryptamine receptor 3A  (5-HT3A)
 
Protein also known as:  Serotonin-gated ion channel receptor.
Gene name:  HTR3A
Entry whose protein(s) existence is based on evidence at protein level
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1 97 5
GENE REF ISO

Function

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Overview 
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.2.1  
GO molecular function 
Receptor activitydefinition[GO:0004872]  
1
  • PINC
Serotonin bindingdefinition[GO:0051378]  
1
  • MGI
Serotonin receptor activitydefinition[GO:0004993]  
1
  • MGI
Serotonin-activated cation-selective channel activitydefinition[GO:0005232] silver  
1
  • Ortholog Compara
Voltage-gated potassium channel activitydefinition[GO:0005249] silver  
1
  • Ortholog Compara
GO biological process 
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
1
  • Ortholog Compara
Digestiondefinition[GO:0007586]  
1
  • PINC
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
1
  • Ortholog Compara
Response to cocainedefinition[GO:0042220] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
1
  • GOC
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ligand-gated ion channel transport  REACT_25387  
Note 
The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HTR3A
GenomeRNAi: 3359
PRO: PR:P46098
Chemistry
GuidetoPHARMACOLOGY: 373