ATRX - Transcriptional regulator ATRX - human protein (Function)
 
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ATRX »  Transcriptional regulator ATRX   [ EC 3.6.4.12 ]
 
Protein also known as:  ATP-dependent helicase ATRX.
Gene name:  ATRX
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
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1 85 6
GENE REF ISO

Function

 show evidences
Overview 
Could be a global transcriptional regulator. Modifies gene expression by affecting chromatin. May be involved in brain development and facial morphogenesis.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Chromo shadow domain bindingdefinition[GO:0070087]  
1
  • IPIBHF-UCL
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
DNA helicase activitydefinition[GO:0003678]  
1
  • TASPINC
DNA translocase activitydefinition[GO:0015616]  
1
  • IDAUniProtKB
Helicase activitydefinition[GO:0004386]  
1
  • TASPINC
Histone bindingdefinition[GO:0042393]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Cellular response to hydroxyureadefinition[GO:0072711]  
  • ISSOrtholog Curator
DNA damage response, signal transduction by p53 class mediatordefinition[GO:0030330]  
  • ISSOrtholog Curator
DNA duplex unwindingdefinition[GO:0032508]  
1
  • TASGOC
DNA methylationdefinition[GO:0006306]  
1
  • TASPINC
DNA recombinationdefinition[GO:0006310]  
1
  • TASPINC
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
DNA replication-independent nucleosome assemblydefinition[GO:0006336]  
1
  • IMPUniProtKB
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Negative regulation of telomeric RNA transcription from RNA pol II promoterdefinition[GO:1901581]  
  • ISSOrtholog Curator
Positive regulation of nuclear cell cycle DNA replicationdefinition[GO:0010571]  
  • ISSOrtholog Curator
Positive regulation of telomere maintenancedefinition[GO:0032206]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASPINC
Replication fork processingdefinition[GO:0031297]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATRX
GenomeRNAi: 546
PRO: PR:P46100