CRK - Adapter molecule crk - human protein (Function)
 
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CRK »  Adapter molecule crk
 
Protein also known as:  Proto-oncogene c-Crk.
Gene name:  CRK
Family name: CRK
Entry whose protein(s) existence is based on evidence at protein level
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1 102 2
GENE REF ISO

Function

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Overview 
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.  
3
  • CuratedUniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
20
  • IPIIntAct
  • IPIUniProtKB
Protein phosphorylated amino acid bindingdefinition[GO:0045309] silver  
  • IEAOrtholog Compara
SH2 domain bindingdefinition[GO:0042169]  
1
  • IPIUniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070] silver  
  • IEAOrtholog Compara
GO biological process 
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • IDAUniProtKB
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • IDAUniProtKB
Regulation of Rac protein signal transductiondefinition[GO:0035020] silver  
  • IEAOrtholog Compara
Regulation of Rho GTPase activitydefinition[GO:0032319]  
1
  • IDAUniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+1398  
Chemokine signaling pathway  hsa04062+1398  
Chronic myeloid leukemia  hsa05220+1398  
ErbB signaling pathway  hsa04012+1398  
Fc gamma R-mediated phagocytosis  hsa04666+1398  
Focal adhesion  hsa04510+1398  
Insulin signaling pathway  hsa04910+1398  
MAPK signaling pathway  hsa04010+1398  
Neurotrophin signaling pathway  hsa04722+1398  
Pathways in cancer  hsa05200+1398  
Regulation of actin cytoskeleton  hsa04810+1398  
Renal cell carcinoma  hsa05211+1398  
Shigellosis  hsa05131+1398  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CRK_(gene)
GenomeRNAi: 1398
PRO: PR:P46108