CRK - Adapter molecule crk - human protein (Function)
 
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Protein
Gene
References

 
CRK »  Adapter molecule crk
 
Protein also known as:  Proto-oncogene c-Crk.
Gene name:  CRK
Family name: CRK
Entry whose protein(s) existence is based on evidence at protein level
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1 227 2
GENE REF ISO

Function

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Overview 
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.  
4
  • UniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
27
  • IntAct
  • UniProtKB
Protein phosphorylated amino acid bindingdefinition[GO:0045309] silver  
1
  • Ortholog Compara
SH2 domain bindingdefinition[GO:0042169]  
1
  • UniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070] silver  
1
  • Ortholog Compara
GO biological process 
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • UniProtKB
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • UniProtKB
Regulation of GTPase activitydefinition[GO:0043087]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+1398  
Chemokine signaling pathway  hsa04062+1398  
Chronic myeloid leukemia  hsa05220+1398  
ErbB signaling pathway  hsa04012+1398  
Fc gamma R-mediated phagocytosis  hsa04666+1398  
Focal adhesion  hsa04510+1398  
Insulin signaling pathway  hsa04910+1398  
MAPK signaling pathway  hsa04010+1398  
Neurotrophin signaling pathway  hsa04722+1398  
Pathways in cancer  hsa05200+1398  
Regulation of actin cytoskeleton  hsa04810+1398  
Renal cell carcinoma  hsa05211+1398  
Shigellosis  hsa05131+1398  
According to Reactome, this protein belongs to the following pathways:
ARMS-mediated activation  REACT_12002  
Downstream signal transduction  REACT_17025  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Regulation of signaling by CBL  REACT_23787  
Signal attenuation  REACT_508  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CRK_(gene)
GenomeRNAi: 1398
PRO: PR:P46108