NSF - Vesicle-fusing ATPase - human protein (Function)
 
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NSF »  Vesicle-fusing ATPase   [ EC 3.6.4.6 ]
 
Protein also known as:  N-ethylmaleimide-sensitive fusion protein (NEM-sensitive fusion protein).
Gene name:  NSF
Family name: AAA ATPase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 1
GENE REF ISO

Function

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Overview 
Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupleddefinition[GO:0042623] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
  • ISSOrtholog Curator
Syntaxin-1 bindingdefinition[GO:0017075]  
  • ISSOrtholog Curator
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAOrtholog Compara
Exocytosisdefinition[GO:0006887]  
1
  • TASUniProtKB
Plasma membrane fusiondefinition[GO:0045026]  
1
  • TASUniProtKB
Positive regulation of receptor recyclingdefinition[GO:0001921]  
1
  • IDAUniProtKB
Potassium ion transportdefinition[GO:0006813] silver  
  • IEAOrtholog Compara
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.6: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+4905  
Synaptic vesicle cycle  hsa04721+4905  
Vasopressin-regulated water reabsorption  hsa04962+4905  
According to Reactome, this protein belongs to the following pathway:
Trafficking of GluR2-containing AMPA receptors  REACT_18422  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links