CDKN1B - Cyclin-dependent kinase inhibitor 1B - human protein (Function)
 
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CDKN1B »  Cyclin-dependent kinase inhibitor 1B
 
Protein also known as:  Cyclin-dependent kinase inhibitor p27.
Gene name:  CDKN1B
Family name: CDI
Entry whose protein(s) existence is based on evidence at protein level
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1 549 1
GENE REF ISO

Function

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Overview 
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.  
5
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087] silver  
  • IEAOrtholog Compara
Cyclin-dependent protein serine/threonine kinase inhibitor activitydefinition[GO:0004861] silver  
  • IEAOrtholog Compara
Contributes to cysteine-type endopeptidase activator activity involved in apoptotic processdefinition[GO:0008656]  
1
  • IDAUniProtKB
Hsp70 protein bindingdefinition[GO:0030544] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
26
  • IPIIntAct
  • IPIHGNC
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIBHF-UCL
Transforming growth factor beta receptor, cytoplasmic mediator activitydefinition[GO:0005072]  
1
  • TASPINC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDAUniProtKB
Autophagic cell deathdefinition[GO:0048102]  
1
  • IDABHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • IMPHGNC
Cellular response to antibioticdefinition[GO:0071236] silver  
  • IEAOrtholog Compara
Cellular response to lithium iondefinition[GO:0071285]  
1
  • IDAMGI
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IDABHF-UCL
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Mitotic cell cycle arrestdefinition[GO:0071850]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Negative regulation of cellular component movementdefinition[GO:0051271] silver  
  • IEAOrtholog Compara
Negative regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045736] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferation involved in prostate gland developmentdefinition[GO:0060770] silver  
  • IEAOrtholog Compara
Negative regulation of kinase activitydefinition[GO:0033673]  
1
  • IDAUniProtKB
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • IDAUniProtKB
Negative regulation of phosphorylationdefinition[GO:0042326]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Positive regulation of cell deathdefinition[GO:0010942]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of microtubule polymerizationdefinition[GO:0031116] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • IDAMGI
Potassium ion transportdefinition[GO:0006813] silver  
  • IEAOrtholog Compara
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • TASPINC
Response to amino aciddefinition[GO:0043200] silver  
  • IEAOrtholog Compara
Response to cadmium iondefinition[GO:0046686] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+1027  
Chronic myeloid leukemia  hsa05220+1027  
ErbB signaling pathway  hsa04012+1027  
Measles  hsa05162+1027  
Pathways in cancer  hsa05200+1027  
Prostate cancer  hsa05215+1027  
Small cell lung cancer  hsa05222+1027  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
Disease  REACT_116125  
DNA Replication  REACT_383  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
Note 
Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Protein kinase inhibitor  definition   [KW-0649]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDKN1B
GenomeRNAi: 1027
PRO: PR:P46527