NOTCH1 - Neurogenic locus notch homolog protein 1 - human protein (Function)
 
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NOTCH1 »  Neurogenic locus notch homolog protein 1  (Notch 1)
 
Protein also known as:  Translocation-associated notch protein TAN-1. Cleaved into:  Notch 1 extracellular truncation; Notch 1 intracellular domain.
Gene name:  NOTCH1
Family name: NOTCH
Entry whose protein(s) existence is based on evidence at protein level
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1 639 1
GENE REF ISO

Function

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Overview 
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Chromatin DNA bindingdefinition[GO:0031490] silver  
  • IEAOrtholog Compara
Core promoter bindingdefinition[GO:0001047]  
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
  • ISSOrtholog Curator
Enzyme inhibitor activitydefinition[GO:0004857]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872] silver  
  • IEAInterPro 2 GO
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Anagendefinition[GO:0042640] silver  
  • IEAOrtholog Compara
Aortic valve morphogenesisdefinition[GO:0003180]  
2
  • IMPBHF-UCL
Apoptotic process involved in embryonic digit morphogenesisdefinition[GO:1902263] silver  
  • IEAOrtholog Compara
Arterial endothelial cell differentiationdefinition[GO:0060842]  
  • ISSOrtholog Curator
Atrioventricular node developmentdefinition[GO:0003162] silver  
  • IEAOrtholog Compara
Atrioventricular valve morphogenesisdefinition[GO:0003181]  
  • ISSOrtholog Curator
Auditory receptor cell fate commitmentdefinition[GO:0009912] silver  
  • IEAOrtholog Compara
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Branching morphogenesis of an epithelial tubedefinition[GO:0048754] silver  
  • IEAOrtholog Compara
Cardiac atrium morphogenesisdefinition[GO:0003209]  
  • ISSOrtholog Curator
Cardiac chamber formationdefinition[GO:0003207]  
  • ISSOrtholog Curator
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317]  
  • ISSOrtholog Curator
Cardiac left ventricle morphogenesisdefinition[GO:0003214]  
  • ISSOrtholog Curator
Cardiac muscle cell proliferationdefinition[GO:0060038] silver  
  • IEAOrtholog Compara
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
  • ISSOrtholog Curator
Cardiac right atrium morphogenesisdefinition[GO:0003213]  
  • ISSOrtholog Curator
Cardiac right ventricle formationdefinition[GO:0003219] silver  
  • IEAOrtholog Compara
Cardiac septum morphogenesisdefinition[GO:0060411]  
  • ISSOrtholog Curator
Cardiac vascular smooth muscle cell developmentdefinition[GO:0060948]  
  • ISSOrtholog Curator
Cardiac ventricle morphogenesisdefinition[GO:0003208]  
  • ISSOrtholog Curator
Cell fate specificationdefinition[GO:0001708] silver  
  • IEAOrtholog Compara
Cell migration involved in endocardial cushion formationdefinition[GO:0003273]  
  • ISSOrtholog Curator
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372]  
1
  • IDABHF-UCL
Cellular response to vascular endothelial growth factor stimulusdefinition[GO:0035924]  
1
  • IDAUniProtKB
Cilium morphogenesisdefinition[GO:0060271]  
  • ISSOrtholog Curator
Collecting duct developmentdefinition[GO:0072044] silver  
  • IEAOrtholog Compara
Compartment pattern specificationdefinition[GO:0007386] silver  
  • IEAOrtholog Compara
Coronary artery morphogenesisdefinition[GO:0060982]  
  • ISSOrtholog Curator
Coronary vein morphogenesisdefinition[GO:0003169]  
  • ISSOrtholog Curator
Determination of left/right symmetrydefinition[GO:0007368]  
  • ISSOrtholog Curator
Distal tubule developmentdefinition[GO:0072017] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Endocardial cell differentiationdefinition[GO:0060956]  
  • ISSOrtholog Curator
Endocardial cushion morphogenesisdefinition[GO:0003203]  
  • ISSOrtholog Curator
Endocardium developmentdefinition[GO:0003157]  
  • ISSOrtholog Curator
Endocardium morphogenesisdefinition[GO:0003160]  
  • ISSOrtholog Curator
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
  • ISSOrtholog Curator
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Foregut morphogenesisdefinition[GO:0007440] silver  
  • IEAOrtholog Compara
Glial cell differentiationdefinition[GO:0010001] silver  
  • IEAOrtholog Compara
Glomerular mesangial cell developmentdefinition[GO:0072144] silver  
  • IEAOrtholog Compara
Growth involved in heart morphogenesisdefinition[GO:0003241]  
  • ISSOrtholog Curator
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • IMPDFLAT
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
Heart trabecula morphogenesisdefinition[GO:0061384]  
  • ISSOrtholog Curator
Humoral immune responsedefinition[GO:0006959] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
  • IEAOrtholog Compara
Interleukin-4 secretiondefinition[GO:0072602] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IEAOrtholog Compara
Left/right axis specificationdefinition[GO:0070986] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mesenchymal cell developmentdefinition[GO:0014031]  
  • ISSOrtholog Curator
Mitral valve formationdefinition[GO:0003192]  
1
  • IMPBHF-UCL
Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPBHF-UCL
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
  • ISSOrtholog Curator
Negative regulation of calcium ion-dependent exocytosisdefinition[GO:0045955] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090] silver  
  • IEAOrtholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
  • ISSOrtholog Curator
Negative regulation of cell migration involved in sprouting angiogenesisdefinition[GO:0090051]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of cell-substrate adhesiondefinition[GO:0010812]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell chemotaxisdefinition[GO:2001027]  
1
  • IDAUniProtKB
Negative regulation of glial cell proliferationdefinition[GO:0060253]  
  • ISSOrtholog Curator
Negative regulation of myoblast differentiationdefinition[GO:0045662]  
1
  • IMPUniProtKB
Negative regulation of myotube differentiationdefinition[GO:0010832]  
  • ISSOrtholog Curator
Negative regulation of neurogenesisdefinition[GO:0050768]  
  • ISSOrtholog Curator
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715]  
  • ISSOrtholog Curator
Negative regulation of ossificationdefinition[GO:0030279]  
  • ISSOrtholog Curator
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
  • ISSOrtholog Curator
Negative regulation of photoreceptor cell differentiationdefinition[GO:0046533] silver  
  • IEAOrtholog Compara
Negative regulation of pro-B cell differentiationdefinition[GO:2000974]  
  • ISSOrtholog Curator
Negative regulation of stem cell differentiationdefinition[GO:2000737]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Neural tube developmentdefinition[GO:0021915] silver  
  • IEAOrtholog Compara
Neuronal stem cell maintenancedefinition[GO:0097150]  
1
  • IEPUniProtKB
Notch signaling involved in heart developmentdefinition[GO:0061314]  
2
  • IMPBHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
2
  • IMPUniProtKB
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferationdefinition[GO:0003270] silver  
  • IEAOrtholog Compara
Pericardium morphogenesisdefinition[GO:0003344]  
  • ISSOrtholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711]  
  • ISSOrtholog Curator
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
  • ISSOrtholog Curator
Positive regulation of cell migrationdefinition[GO:0030335]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
1
  • IMPBHF-UCL
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
  • ISSOrtholog Curator
Positive regulation of keratinocyte differentiationdefinition[GO:0045618] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxiadefinition[GO:0061419]  
  • ISSOrtholog Curator
Positive regulation of transcription of Notch receptor targetdefinition[GO:0007221]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Prostate gland epithelium morphogenesisdefinition[GO:0060740] silver  
  • IEAOrtholog Compara
Pulmonary valve morphogenesisdefinition[GO:0003184]  
1
  • IMPBHF-UCL
Regulation of epithelial cell proliferation involved in prostate gland developmentdefinition[GO:0060768] silver  
  • IEAOrtholog Compara
Regulation of extracellular matrix assemblydefinition[GO:1901201]  
  • ISSOrtholog Curator
Regulation of somitogenesisdefinition[GO:0014807] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationdefinition[GO:0003256]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASUniProtKB
Response to muramyl dipeptidedefinition[GO:0032495] silver  
  • IEAOrtholog Compara
Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentdefinition[GO:0060528] silver  
  • IEAOrtholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Somatic stem cell divisiondefinition[GO:0048103] silver  
  • IEAOrtholog Compara
Sprouting angiogenesisdefinition[GO:0002040] silver  
  • IEAOrtholog Compara
Tube formationdefinition[GO:0035148]  
1
  • IMPUniProtKB
Vasculogenesis involved in coronary vascular morphogenesisdefinition[GO:0060979]  
  • ISSOrtholog Curator
Venous endothelial cell differentiationdefinition[GO:0060843]  
  • ISSOrtholog Curator
Ventricular septum morphogenesisdefinition[GO:0060412]  
1
  • IMPBHF-UCL
Ventricular trabecula myocardium morphogenesisdefinition[GO:0003222]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dorso-ventral axis formation  hsa04320+4851  
Notch signaling pathway  hsa04330+4851  
Prion diseases  hsa05020+4851  
According to Reactome, this protein belongs to the following pathways:
A third proteolytic cleavage releases NICD  REACT_691  
Disease  REACT_116125  
Gene Expression  REACT_71  
NICD traffics to nucleus  REACT_2155  
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor  REACT_2001  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Notch-1
GenomeRNAi: 4851
PRO: PR:P46531