ASMT - Acetylserotonin O-methyltransferase - human protein (Function)
 
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ASMT »  Acetylserotonin O-methyltransferase   [ EC 2.1.1.4 ]
 
Protein also known as:  Hydroxyindole O-methyltransferase (HIOMT).
Gene name:  ASMT
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 3
GENE REF ISO

Function

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Overview 
Isoforms  Iso 2 and Iso 3   Lack enzyme activity.  
1
  • CuratedUniProtKB
Isoform  Iso 1   Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).  
1
  • CuratedUniProtKB
GO molecular function 
Acetylserotonin O-methyltransferase activitydefinition[GO:0017096]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
O-methyltransferase activitydefinition[GO:0008171]  
1
  • TASPINC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
GO biological process 
Melatonin biosynthetic processdefinition[GO:0030187]  
1
  • IDAUniProtKB
  • IEAUniPathway
Negative regulation of male gonad developmentdefinition[GO:2000019] silver  
  • IEAOrtholog Compara
Translationdefinition[GO:0006412]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.4: S-adenosyl-L-methionine + N-acetylserotonin S-adenosyl-L-homocysteine + melatonin.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+438  
Tryptophan metabolism  hsa00380+438  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Melatonin biosynthesis  definition   [KW-0471]
Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links