BDKRB1 - B1 bradykinin receptor - human protein (Function)
 
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BDKRB1 »  B1 bradykinin receptor  (B1R)
 
Gene name:  BDKRB1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.  
  • CuratedUniProtKB
GO molecular function 
Bradykinin receptor activitydefinition[GO:0004947] silver  
  • IEAOrtholog Compara
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell migrationdefinition[GO:0016477] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
  • IEAOrtholog Compara
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAInterPro 2 GO
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+623  
Complement and coagulation cascades  hsa04610+623  
Neuroactive ligand-receptor interaction  hsa04080+623  
Regulation of actin cytoskeleton  hsa04810+623  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Bradykinin_receptor_B1
GenomeRNAi: 623
PRO: PR:P46663
Chemistry
GuidetoPHARMACOLOGY: 41