IER3 - Radiation-inducible immediate-early gene IEX-1 - human protein (Function)
 
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IER3 »  Radiation-inducible immediate-early gene IEX-1
 
Protein also known as:  Differentiation-dependent gene 2 protein (Protein DIF-2).
Gene name:  IER3
Family name: IER3
Entry whose protein(s) existence is based on evidence at protein level
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6 38 1
GENE REF ISO

Function

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Overview 
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Mitotic G2 DNA damage checkpointdefinition[GO:0007095] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAInterPro 2 GO
Negative regulation of glycolytic processdefinition[GO:0045820] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaydefinition[GO:1901029] silver  
  • IEAOrtholog Compara
Negative regulation of systemic arterial blood pressuredefinition[GO:0003085] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732] silver  
  • IEAOrtholog Compara
Regulation of DNA repairdefinition[GO:0006282] silver  
  • IEAOrtholog Compara
Regulation of nucleocytoplasmic transportdefinition[GO:0046822] silver  
  • IEAOrtholog Compara
Regulation of reactive oxygen species metabolic processdefinition[GO:2000377] silver  
  • IEAOrtholog Compara
Regulation of response to DNA damage stimulusdefinition[GO:2001020]  
1
  • IMPMGI
Response to protozoandefinition[GO:0001562] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IER3
GenomeRNAi: 8870
PRO: PR:P46695