MAP2K3 - Dual specificity mitogen-activated protein kinase kinase 3 - human protein (Function)
 
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MAP2K3 »  Dual specificity mitogen-activated protein kinase kinase 3   [ EC 2.7.12.2 ]  (MAPKK 3)
 
Protein also known as:  Stress-activated protein kinase kinase 2 (SAPKK2).
Gene name:  MAP2K3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 3
GENE REF ISO

Function

 show evidences
Overview 
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase kinase activitydefinition[GO:0004708] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IBARefGenome
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of cytokine biosynthetic processdefinition[GO:0042035] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.2: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by dual phosphorylation on Ser-218 and Thr-222.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+5606  
Fc epsilon RI signaling pathway  hsa04664+5606  
GnRH signaling pathway  hsa04912+5606  
Influenza A  hsa05164+5606  
MAPK signaling pathway  hsa04010+5606  
Toll-like receptor signaling pathway  hsa04620+5606  
Toxoplasmosis  hsa05145+5606  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Immune System  REACT_6900  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP2K3
GenomeRNAi: 5606
PRO: PR:P46734
Chemistry
GuidetoPHARMACOLOGY: 2064