BRCC3 - Lys-63-specific deubiquitinase BRCC36 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
BRCC3 »  Lys-63-specific deubiquitinase BRCC36   [ EC 3.4.19.- ]
 
Protein also known as:  BRCA1/BRCA2-containing complex subunit 36.
Gene name:  BRCC3
Family name: Peptidase M67A » BRCC36
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 5
GENE REF ISO

Function

 show evidences
Overview 
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.  
8
  • CuratedUniProtKB
GO molecular function 
Enzyme regulator activitydefinition[GO:0030234]  
1
  • IDAMGI
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
4
  • IMPUniProtKB
Polyubiquitin bindingdefinition[GO:0031593]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Ubiquitin thiolesterase activitydefinition[GO:0004221]  
3
  • IMPUniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IMPUniProtKB
GO biological process 
Double-strand break repairdefinition[GO:0006302]  
3
  • IMPUniProtKB
G2 DNA damage checkpointdefinition[GO:0031572]  
3
  • IMPUniProtKB
Histone H2A K63-linked deubiquitinationdefinition[GO:0070537]  
2
  • IMPUniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
3
  • IMPUniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
2
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Response to ionizing radiationdefinition[GO:0010212]  
3
  • IMPUniProtKB
Response to X-raydefinition[GO:0010165]  
1
  • IDAMGI
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BRCC3
GenomeRNAi: 79184
PRO: PR:P46736