NEDD4 - E3 ubiquitin-protein ligase NEDD4 - human protein (Function)
 
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NEDD4 »  E3 ubiquitin-protein ligase NEDD4   [ EC 6.3.2.- ]
 
Protein also known as:  Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD-4).
Gene name:  NEDD4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 126 4
GENE REF ISO

Function

 show evidences
Overview 
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.  
7
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nedd4-family interacting protein-2 (nedd4) family  8.A.30.1.2  
GO molecular function 
Beta-2 adrenergic receptor bindingdefinition[GO:0031698]  
1
  • IDAUniProtKB
Phosphoserine bindingdefinition[GO:0050815]  
  • ISSOrtholog Curator
Phosphothreonine bindingdefinition[GO:0050816]  
  • ISSOrtholog Curator
Proline-rich region bindingdefinition[GO:0070064]  
2
  • IMPBHF-UCL
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
RNA polymerase bindingdefinition[GO:0070063]  
1
  • IPIBHF-UCL
Sodium channel inhibitor activitydefinition[GO:0019871]  
1
  • IDABHF-UCL
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IDABHF-UCL
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
2
  • IDABHF-UCL
GO biological process 
Adaptive immune responsedefinition[GO:0002250] silver  
  • IEAOrtholog Compara
Blood vessel morphogenesisdefinition[GO:0048514] silver  
  • IEAOrtholog Compara
Cellular response to UVdefinition[GO:0034644]  
1
  • IMPBHF-UCL
Development involved in symbiotic interactiondefinition[GO:0044111]  
1
  • IMPUniProtKB
Endocardial cushion developmentdefinition[GO:0003197] silver  
  • IEAOrtholog Compara
Glucocorticoid receptor signaling pathwaydefinition[GO:0042921]  
1
  • IDABHF-UCL
Lysosomal transportdefinition[GO:0007041]  
1
  • IDAUniProtKB
Negative regulation of sodium ion transportdefinition[GO:0010766]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damagedefinition[GO:0010768]  
1
  • IMPBHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030948]  
  • ISSOrtholog Curator
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • IEPBHF-UCL
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Positive regulation of nucleocytoplasmic transportdefinition[GO:0046824]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IMPBHF-UCL
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • IDAMGI
Progesterone receptor signaling pathwaydefinition[GO:0050847]  
1
  • IDABHF-UCL
Protein K63-linked ubiquitinationdefinition[GO:0070534]  
  • ISSOrtholog Curator
Protein monoubiquitinationdefinition[GO:0006513] silver  
  • IEAOrtholog Compara
Protein targeting to lysosomedefinition[GO:0006622]  
1
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDAUniProtKB
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
3
  • IDABHF-UCL
Receptor catabolic processdefinition[GO:0032801]  
1
  • IDAUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Regulation of dendrite morphogenesisdefinition[GO:0048814]  
  • ISSOrtholog Curator
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • IDABHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Regulation of potassium ion transmembrane transporter activitydefinition[GO:1901016]  
1
  • IDABHF-UCL
Regulation of synapse organizationdefinition[GO:0050807] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592]  
1
  • TASBHF-UCL
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Transmission of virusdefinition[GO:0019089]  
1
  • IMPBHF-UCL
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043162]  
1
  • IMPBHF-UCL
Enzymatic activity 
It is regulated in the following manner
Activated by NDFIP1- and NDFIP2-binding (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
Note 
A cysteine residue is required for ubiquitin-thioester formation.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Neurogenesis  definition   [KW-0524]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NEDD4
GenomeRNAi: 4734
PRO: PR:P46934