GALR1 - Galanin receptor type 1 - human protein (Function)
 
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GALR1 »  Galanin receptor type 1  (GALR-1)
 
Gene name:  GALR1
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.  
  • CuratedUniProtKB
GO molecular function 
Galanin receptor activitydefinition[GO:0004966]  
1
  • IDAUniProtKB
Neuropeptide bindingdefinition[GO:0042923] silver  
  • IEAOrtholog Compara
Peptide hormone bindingdefinition[GO:0017046]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Negative regulation of adenylate cyclase activitydefinition[GO:0007194] silver  
  • IEAInterPro 2 GO
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • TASPINC
Positive regulation of cortisol secretiondefinition[GO:0051464]  
1
  • IMPUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAInterPro 2 GO
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2587  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Galanin_receptor_1
GenomeRNAi: 2587
PRO: PR:P47211
Chemistry
GuidetoPHARMACOLOGY: 243