GCGR - Glucagon receptor - human protein (Function)
 
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GCGR »  Glucagon receptor  (GL-R)
 
Gene name:  GCGR
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.  
5
  • CuratedUniProtKB
GO molecular function 
Glucagon receptor activitydefinition[GO:0004967]  
1
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • IMPUniProtKB
Cellular response to glucagon stimulusdefinition[GO:0071377]  
1
  • IDAUniProtKB
Exocytosisdefinition[GO:0006887] silver  
  • IEAOrtholog Compara
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Regulation of glycogen metabolic processdefinition[GO:0070873]  
  • ISSOrtholog Curator
Response to nutrientdefinition[GO:0007584]  
1
  • TASPINC
Response to starvationdefinition[GO:0042594]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2642  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glucagon_receptor
GenomeRNAi: 2642
PRO: PR:P47871
Chemistry
GuidetoPHARMACOLOGY: 251