GCGR - Glucagon receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GCGR »  Glucagon receptor  (GL-R)
 
Gene name:  GCGR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 1
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.  
6
  • UniProtKB
GO molecular function 
Glucagon receptor activitydefinition[GO:0004967]  
1
  • UniProtKB
Peptide hormone bindingdefinition[GO:0017046] silver  
1
  • Ortholog Compara
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
1
  • Ortholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • UniProtKB
Cellular response to glucagon stimulusdefinition[GO:0071377]  
1
  • UniProtKB
Exocytosisdefinition[GO:0006887] silver  
1
  • Ortholog Compara
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • PINC
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
1
  • Ortholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
1
  • PINC
Regulation of glycogen metabolic processdefinition[GO:0070873]  
1
  • Ortholog Curator
Response to nutrientdefinition[GO:0007584]  
1
  • PINC
Response to starvationdefinition[GO:0042594]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2642  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-type ligand receptors  REACT_18377  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glucagon_receptor
GenomeRNAi: 2642
PRO: PR:P47871
Chemistry
GuidetoPHARMACOLOGY: 251