ALDH1A3 - Aldehyde dehydrogenase family 1 member A3 - human protein (Function)
 
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ALDH1A3 »  Aldehyde dehydrogenase family 1 member A3   [ EC 1.2.1.5 ]
 
Protein also known as:  Retinaldehyde dehydrogenase 3 (RalDH3).
Gene name:  ALDH1A3
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 23 1
GENE REF ISO

Function

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Overview 
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029] silver  
  • IEAOrtholog Compara
Aldehyde dehydrogenase [NAD(P)+] activitydefinition[GO:0004030]  
1
  • IDAUniProtKB
NAD+ bindingdefinition[GO:0070403] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Thyroid hormone bindingdefinition[GO:0070324] silver  
  • IEAOrtholog Compara
GO biological process 
Embryonic eye morphogenesisdefinition[GO:0048048]  
  • ISSOrtholog Curator
Face developmentdefinition[GO:0060324] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Nucleus accumbens developmentdefinition[GO:0021768] silver  
  • IEAOrtholog Compara
Olfactory pit developmentdefinition[GO:0060166] silver  
  • IEAOrtholog Compara
Optic cup morphogenesis involved in camera-type eye developmentdefinition[GO:0002072] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Retinal metabolic processdefinition[GO:0042574]  
1
  • IDAUniProtKB
Retinoic acid biosynthetic processdefinition[GO:0002138] silver  
  • IEAOrtholog Compara
Retinoic acid metabolic processdefinition[GO:0042573]  
1
  • IDAUniProtKB
Retinol metabolic processdefinition[GO:0042572]  
  • IEAUniPathway
Righting reflexdefinition[GO:0060013] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.5: An aldehyde + NAD(P)(+) + H(2)O a carboxylate + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+220  
Drug metabolism - cytochrome P450  hsa00982+220  
Glycolysis / Gluconeogenesis  hsa00010+220  
Histidine metabolism  hsa00340+220  
Metabolic pathways  hsa01100+220  
Metabolism of xenobiotics by cytochrome P450  hsa00980+220  
Phenylalanine metabolism  hsa00360+220  
Tyrosine metabolism  hsa00350+220  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALDH1A3
GenomeRNAi: 220
PRO: PR:P47895