QARS - Glutamine--tRNA ligase - human protein (Function)
 
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References

 
QARS »  Glutamine--tRNA ligase   [ EC 6.1.1.18 ]
 
Protein also known as:  Glutaminyl-tRNA synthetase (GlnRS).
Gene name:  QARS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

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Overview 
Plays a critical role in brain development.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420]  
1
  • UniProtKB
Glutaminyl-tRNA aminoacylationdefinition[GO:0006425]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.18: ATP + L-glutamine + tRNA(Gln) AMP + diphosphate + L-glutaminyl-tRNA(Gln).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aminoacyl-tRNA biosynthesis  hsa00970+5859  
Metabolic pathways  hsa01100+5859  
According to Reactome, this protein belongs to the following pathways:
Cytosolic tRNA aminoacylation  REACT_15306  
Mitochondrial tRNA aminoacylation  REACT_15302  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: QARS
GenomeRNAi: 5859
PRO: PR:P47897
Protein family/group databases
MoonProt: P47897