HTR5A - 5-hydroxytryptamine receptor 5A - human protein (Function)
 
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HTR5A »  5-hydroxytryptamine receptor 5A  (5-HT5A)
 
Protein also known as:  Serotonin receptor 5A.
Gene name:  HTR5A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.  
  • CuratedUniProtKB
GO molecular function 
Serotonin receptor activitydefinition[GO:0004993]  
1
  • IDAMGI
GO biological process 
cAMP-mediated signalingdefinition[GO:0019933] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187] silver  
  • IEAOrtholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
1
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3361  
Neuroactive ligand-receptor interaction  hsa04080+3361  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Serotonin receptors  REACT_17064  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT5A_receptor
GenomeRNAi: 3361
PRO: PR:P47898
Chemistry
GuidetoPHARMACOLOGY: 10